ADAPALENE

Product Description

is among world’s top most manufacturer,supplier, exporter and trader of the Adapalene finishedformulations moreover Adapalene API.Niksan Pharmaceutical is the huge manufacturer, exporter and supplier of Adapalene API and formulation situated inAnkleshwar, Gujarat, India.

Niksan Pharmaceutical provides API and finishedformulations of Adapalene in allover Indian states Like Meghalaya, Tamilnadu, Goa, Sikkim, Assam, Punjab,Delhi, Bihar, Kerala, Gujarat, Haryana, Rajasthan, Madhya Pradesh, Uttar Pradesh,Rajasthan, Karnataka, Jammu Kashmir Etc.

Niksan pharmaceutical is also large exporter ofthe API and finished pharmaceutical products of Adapalene in many countries for years. The countries where weexporting are Nepal, Sri Lanka, Malaysia, Philippines, Kenya, Singapore, HongKong, Pakistan, United Arab Emirates, United States, Puerto Rico, Argentina,Egypt, Qatar, Taiwan, Algeria, Jordan, Uruguay, United Kingdom, Canada,Bangladesh, New Zealand, Saudi Arabia, Australia, Colombia, France, Vietnam,Ireland, Iraq, Thailand, South Africa, Ecuador, Serbia, Peru, Indonesia,Morocco, Israel, Greece, Romania, Mexico, Iran, Switzerland, Norway, Italy,Denmark, Belgium, South Korea, Netherlands, Venezuela, Hungary, Chile, Sweden,Germany, Ukraine, Spain, Poland, Brazil, Turkey, Russia, Japan and many morecountries.

Adapalene is one kind of skin careproduct. Adapalene belongs to the retinoid like compound. Adapalene used inskin care and works by stopping the pimples from forming under the skin.

 

SYNONYMS: Adapalene, Adapalènem, Adapaleno, Adapalenum

 

IUPAC NAME: 6-[3-(adamantan-1-yl)-4-methoxyphenyl] naphthalene-2-carboxylicacid

 

CAS NO: 106685-40-9

 

FORMULA: C₂₈H₂₈O₃

 

MOLECULAR MASS: 412.52 g/mol

 

STORAGE CONDITIONS: Store in cool and dry place, away fromdirect heat and light.

Do not place in bathroom or kitchen. Keep away from the childrenand pet.

 

HOW TO USE: Use this medication on your skin. Wash cleanand dry your skin before using the medication. Wash your hands before using thegel, tube or lotion. Do not apply medicine on eyes.

 

HOW ADAPALENEWORKS: Adapalene works by inhibiting the acne formulation under the skin.Adapalene binds with the retinoid receptor and activates it. Adapalene also usein the beauty care products.

 

PHARMACOKINETICS: Adapalene absorbedthrough skin after topical application, used only 2g of 0.3% gel. The half-lifeof Adapalene 0.3% gel id between 7-51 hours. Almost 25% of drug metabolised inthe body. 75% of drug remains unchanged and eliminated by the biliary route.

 

SIDE EFFECTS: The stinging likesensation occurs after applying the medicine. Side effects like burning,irritation, swelling of skin, itching, dryness of skin, burning are seen in thefirst 5-6 days of using the medicine. If you see side effects like irritation,intense burning, redness of eye, skin discolouration contact your doctor.

 

PRECAUTIONS: Before using themedication tell your doctor if you are allergic to Adapalene. Tell your doctorif you have any problem like skin problem, eczema etc. Do not apply thismedicine on open wounds. Do not apply on eye or burned part of skin.

 

CDSCO APPROVAL: Adapalene 0.1% w/w approved by CDSCO inIndia in 15.03.2001,

Adapalene 0.1% + Benzoyl Peroxide 2.5% gel approved by CDSCO inIndia in 31.10.2008,

Adapalene + clindamycin gel approved by CDSCO in India in01.05.2003

 

FORMULATION AVAILABLE IN MARKET:

Adapalene 0.1% w/w cream

Adapalene 0.1% + Benzoyl Peroxide 2.5% gel

Adapalene + clindamycin gel

Adapalene 0.1% w/w + clindamycin gel 0.1%w/w cream

Adapalene 1%w/w cream

Adapalene 0.1% w/w cream

Adapalene 0.10% w/v gel

Adapalene 0.1% w/w + benzoyl peroxide 2.5%w/w cream

Adapalene 0.02 %w/w + Azithromycin 2 %w/w cream

Adapalene 0.1 %w/v +Allantoin 1 %w/w + Clindamycin 1 %w/w gel

 

Note: Product protected by valid patents are notoffered for sale in countries where such patents are still valid and itsliability is at Buyers Risk

 

REFERENCES:

 

www.webmd.com

https://pubchem.ncbi.nlm.nih.gov

https://go.drugbank.com 

https://cdscoonline.gov.in 

https://www.wikipedia.org/

https://www.drugs.com

https://www.zaubacorp.com

https://www.practo.com/consult